CHANGES IN RESISTANCE TO MOUTH OPENING INDUCED BY DEPOLARIZING AND NON-DEPOLARIZING NEUROMUSCULAR RELAXANTS
نویسندگان
چکیده
منابع مشابه
Changes in resistance to mouth opening induced by depolarizing and non-depolarizing neuromuscular relaxants.
Mouth opening was measured in 43 children anaesthetized with isoflurane and paralysed with vecuronium or suxamethonium. Measurements of mouth opening were made for up to 10 min after loss of the adductor pollicis twitch and cessation of muscle fasciculations. In 22 patients receiving suxamethonium, a significant (P less than 0.001) reduction in mean mouth opening occurred in the 60 s after loss...
متن کاملPharmacodynamics of non-depolarizing neuromuscular blocking agents.
When a clinical dose of a competitive neuromuscular blocking drug is given I.V. to a patient, a period of latency is followed by a progressive onset of blockade until a maximum is reached after several minutes. Thereafter, the intensity of block declines gradually. The precise relationship between the dose of drug and the time-course of the effect is complex, being dependent upon both pharmacok...
متن کاملDenervation supersensitivity: the response to depolarizing muscle relaxants.
The chemical theory of neuromuscular transmission (Dale, Feldberg and Vogt, 1936) is now almost universally accepted, and implicates acetylcholine as the neuromuscular transmitter. Depolarizing muscle relaxants act, at least initially, in a manner similar to acetylcholine and are believed to produce their effects by prolonged depolarization, but in certain situations these agents, instead of pr...
متن کاملRepeated resistance to non-depolarizing neuromuscular blocking drugs in a patient with multiple myeloma.
were taken from this mixture at nine intervals for up to 128 min. Each sample was immediately acidified, stored at — 20 °C and subsequently transferred to Groningen for analysis. All samples revealed vecuronium without any of its breakdown products. Unlike the 3-hydroxy metabolite, neither of the two other metabolites of vecuronium (17-hydroxy and 3,17-dihydroxy vecuronium) have been detected p...
متن کاملInteractions between suxamethonium and non-depolarizing neuromuscular blocking drugs.
In anaesthetized cats, we have confirmed that previously injected suxamethonium potentiates non-depolarizing neuromuscular blocking drugs whereas, when injected during the block, suxamethonium antagonizes the paralysis. We have attempted to explain these interactions by studying the effects of suxamethonium on extracellularly recorded nerve ending waveforms that correspond to the ionic currents...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1990
ISSN: 0007-0912
DOI: 10.1093/bja/64.1.21