Changes in Dried Blood Spot Hb A1c with Varied Postcollection Conditions

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Changes in dried blood spot Hb A1c with varied postcollection conditions.

Diabetes affects Ͼ5% of US adults (15% of those older than 60 years) and is on the rise in adolescents. Gly-cosylated hemoglobin (Hb A 1c), a cumulative marker of blood glucose concentrations over the previous 2 months, has become a powerful clinical tool for diabetes management (1, 2) and is predic-tive of future complications of diabetes (3). Large-scale community-based studies often preclude...

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Critical sample pretreatment in monitoring dried blood spot citrulline.

BACKGROUND Plasma Citrulline concentration has been correlated to functional enterocyte mass. Dried blood spot (DBS) analysis using LC-MSMS reduces sample amount needed. We optimized DBS elution to increase precision and accuracy of DBS LC-MSMS analysis. METHOD DBS control samples were eluted in varying pH (2.2-7.0) and for varying times (15-75 min) and Cit, Arg and Orn were analyzed using LC...

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Stability of Proteins in Dried Blood Spot Biobanks*□S

An important motivation for the construction of biobanks is to discover biomarkers that identify diseases at early, potentially curable stages. This will require biobanks from large numbers of individuals, preferably sampled repeatedly, where the samples are collected and stored under conditions that preserve potential biomarkers. Dried blood samples are attractive for biobanking because of the...

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Stability of Proteins in Dried Blood Spot Biobanks*

An important motivation for the construction of biobanks is to discover biomarkers that identify diseases at early, potentially curable stages. This will require biobanks from large numbers of individuals, preferably sampled repeatedly, where the samples are collected and stored under conditions that preserve potential biomarkers. Dried blood samples are attractive for biobanking because of the...

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ژورنال

عنوان ژورنال: Clinical Chemistry

سال: 2009

ISSN: 0009-9147,1530-8561

DOI: 10.1373/clinchem.2008.111641