Cephalic Axial Skeletal-Neural Dysraphic Disorders: Embryology and Pathology

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چکیده

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Cephalic axial skeletal-neural dysraphic disorders: embryology and pathology.

Three fundamental types of cephalic axial skeletal-neural dysrapic disorders are analyzed, including: cranioschisis aperta with encephaloschisis (anencephaly and/or exencephaly), cranioschisis occulta with occipital encephalocele, and the Chiari malformation (occipital bone hypoplasia) with compression, deformation and displacement of hindbrain, cerebellum, and medulla. Both clinical and experi...

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The notochordal-basichondrocranium relationships have been investigated in cranioschisis occulta with encephalocoele (CSO-EN) and in cranioschisis aperta with exencephaly (CSA-EX) which represent, respectively, a minimal and a severe form of experimentally induced axial skeletal (dysraphic) disorders. Although apparently different, these two malformations are considered to represent different d...

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Through the use of the techniques of experimental embryology, developed by such pioneering artisans as Wilhelm Roux, Hans Spemann, Ross Harrison, Frank Lillie and Viktor Hamburger, as well as their scientific ‘children’, ‘grandchildren’ and more distant ‘relatives’, key principles of neural development have been elucidated (TIMELINE). Although the goal of experimental embryology seems rather si...

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ژورنال

عنوان ژورنال: Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques

سال: 1991

ISSN: 0317-1671,2057-0155

DOI: 10.1017/s0317167100031632