منابع مشابه
New centrally acting antihypertensive drugs related to methyldopa and clonidine.
It has been well established that the antihypertensive drugs clonidine and methyldopa lower blood pressure by acting on postsynaptic alpha 2-adrenergic receptors within cardiovascular control centers of the brain. A number of novel agents designed as lipophilic and highly selective alpha 2-adrenergic stimulants have been synthesized and in general the pharmacological features of these agents re...
متن کاملHemodynamic and cardiac effects of centrally acting antihypertensive drugs.
The centrally acting alpha-adrenergic receptor agonist compounds have been available for treatment of hypertension for more than 25 years. Through studies of these compounds during this time, new knowledge has been made available not only on their mechanisms of antihypertensive action but also on the role of the adrenergic nervous system in essential hypertension. This discussion primarily revi...
متن کاملEffects of centrally acting antihypertensive drugs on the microcirculation of spontaneously hypertensive rats.
We investigated the acute effects of centrally acting antihypertensive drugs on the microcirculation of pentobarbital-anesthetized spontaneously hypertensive rats (SHR). The effects of the sympatho-inhibitory agents clonidine and rilmenidine, known to activate both alpha2-adrenoceptors and nonadrenergic I1-imidazoline binding sites (I1BS) in the central nervous system, were compared to those of...
متن کاملCritical flicker frequency and centrally-acting drugs.
THE critical flicker frequency (cff) may be defined as the fastest rate at which a flickering source of light appears to be flickering as opposed to being steady. It has a number of determinants including the luminance, wave-length, wave-form, and light-dark ratio of the stimulating light, the area, position, and light-adapted state of the retina illuminated, the duration of exposure, and the s...
متن کاملEffect of four centrally acting drugs on handwriting.
Writing is a motor act which is acquired early in life and the performance thereafter remains stable over long periods of time in adult individuals. Successive samples are, thus unlikely to be affected by further practice (1). At the same time, handwriting, being a complex motor act requiring fine co-ordination should be more sensitive to the effects of psychoactive agents than simple skills (2...
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ژورنال
عنوان ژورنال: "Arterial’naya Gipertenziya" ("Arterial Hypertension")
سال: 2006
ISSN: 2411-8524,1607-419X
DOI: 10.18705/1607-419x-2006-12-2-125-130