Central composite rotatable design for optimization of trihalomethane extraction and detection through gas chromatography: a case study

Abstract Central composite rotatable design (CCRD) was employed to optimize initial temperature (ºC), ramp function (ºC/min) and salt addition for trihalomethane extraction/quantification from the drinking water distribution network in Ratta Amral, Rawalpindi., Pakistan. Drinking samples were collected treatment plant, overhead reservoir consumer’s taps. The USEPA method detection 551.1 via gas chromatography applied using liquid–liquid extraction. experiments with input variables sample preparation operational conditions performed a randomized order as per of experiment by central responses evaluated model development. A significant ( p = 0.005) two-factor interaction optimized. Initial observed be insignificant 0.64), while 0.0043) 0.04) significant. Product 0.004), product 0.008). With desirability 0.97, an 50 ºC, 6 ºC rise/min 180 0.5 g It found that development optimization analytical methods rapid would improve current practices country.