Central Amygdala Activity during Fear Conditioning

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Brief Communications Central Amygdala Activity during Fear Conditioning

The central amygdala (Ce), particularly its medial sector (CeM), is the main output station of the amygdala for conditioned fear responses. However, there is uncertainty regarding the nature of CeM control over conditioned fear. The present study aimed to clarify this question using unit recordings in rats. Fear conditioning caused most CeM neurons to increase their conditioned stimulus (CS) re...

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Psychopathy is a personality disorder characterized by emotional deficits and a failure to inhibit impulsive behavior and is often subdivided into "primary" and "secondary" psychopathic subtypes. The maladaptive behavior related to primary psychopathy is thought to reflect constitutional "fearlessness," while the problematic behavior related to secondary psychopathy is motivated by other factor...

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The role of consciousness in learning has been debated for nearly 50 years. Recent studies suggest that conscious awareness is needed to bridge the gap when learning about two events that are separated in time, as is true for trace fear conditioning. This has been repeatedly shown and seems to apply to other forms of classical conditioning as well. In contrast to these findings, we show that in...

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Dissociable amygdala and orbitofrontal responses during reversal fear conditioning.

The neural mechanisms underlying the persistence and plasticity of human emotional learning are unknown. Here we describe dissociable neural responses in amygdala and orbitofrontal cortex during acquisition and reversal of discriminatory fear conditioning. During acquisition, increased responses in bilateral amygdala were elicited by a face stimulus (A = CS+) predictive of an aversive noise com...

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ژورنال

عنوان ژورنال: Journal of Neuroscience

سال: 2011

ISSN: 0270-6474,1529-2401

DOI: 10.1523/jneurosci.4985-10.2011