منابع مشابه
Axonal pathfinding during the regeneration of the goldfish optic pathway.
Retinal ganglion cells in fish and amphibians regenerate their axons after transection of the optic nerve. Fiber tracing studies during the third month of regeneration show that the axons have reestablished a basically normal fiber order in the two brachia of the optic tract; axons originating in the ventral hemiretina are concentrated in the dorsal brachium, axons from the dorsal hemiretina in...
متن کاملAltered levels of Gq activity modulate axonal pathfinding in Drosophila.
A majority of neurons that form the ventral nerve cord send out long axons that cross the midline through anterior or posterior commissures. A smaller fraction extend longitudinally and never cross the midline. The decision to cross the midline is governed by a balance of attractive and repulsive signals. We have explored the role of a G-protein, Galphaq, in altering this balance in Drosophila....
متن کاملDystroglycan Organizes Axon Guidance Cue Localization and Axonal Pathfinding
Precise patterning of axon guidance cue distribution is critical for nervous system development. Using a murine forward genetic screen for novel determinants of axon guidance, we identified B3gnt1 and ISPD as required for the glycosylation of dystroglycan in vivo. Analysis of B3gnt1, ISPD, and dystroglycan mutant mice revealed a critical role for glycosylated dystroglycan in the development of ...
متن کاملMutations affecting retinotectal axonal pathfinding in Medaka, Oryzias latipes
We screened for mutations affecting retinotectal axonal projection in Medaka, Oryzias latipes. In wild-type Medaka embryos, all the axons of retinal ganglion cells (RGCs) project to the contralateral tectum, such that the topological relationship of the retinal field is maintained. We labeled RGC axons using DiI/DiO at the nasodorsal and temporoventral positions of the retina, and screened for ...
متن کاملAxonal pathfinding in the absence of normal pathways and impulse activity.
Retinal axons were challenged to grow to their targets both along abnormal pathways and in the absence of impulse activity. Eye primordia were first transplanted from normal to ectopic sites in axolotl embryos. Most of the hosts were genetically eyeless, others were enucleated normal embryos. These axolotl embryos were then parabiotically joined to California newt embryos. Both operations were ...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Perspectives in Biology
سال: 2010
ISSN: 1943-0264
DOI: 10.1101/cshperspect.a001933