Cellular reprogramming: a small molecule perspective
نویسندگان
چکیده
منابع مشابه
Retraction: small molecule-based reversible reprogramming of cellular lifespan.
In this paper, we described the application of magnetism-based interaction capture (MAGIC) to find a small-molecule protein target. MAGIC identified the protein ATM as the target of CGK733, a small molecule reportedly isolated by high-throughput screening. A preliminary investigation of the contents of the paper by Korean Advanced Institute of Science and Technology (KAIST) has revealed several...
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Entangling and twisting of cellular DNA (i.e., supercoiling) are problems inherent to the helical structure of double-stranded DNA. Supercoiling affects transcription, DNA replication, and chromosomal segregation. Consequently the cell must fine-tune supercoiling to optimize these key processes. Here, we summarize how supercoiling is generated and review experimental and theoretical insights in...
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a:4:{s:10:"Background";s:1707:"Early embryonic development in mammals begins in transcriptional silence with an oocyte-mediated transcriptional reprogramming of parental gametes occurs during a so called across-the-board process of “erase-and-rebuild”. In this process, the parental transcription programs are erased long before (maternal) or soon thereafter (paternal) fertilization to generate a...
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ژورنال
عنوان ژورنال: Current Opinion in Cell Biology
سال: 2012
ISSN: 0955-0674
DOI: 10.1016/j.ceb.2012.08.010