Cellular Inheritance

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Cellular Inheritance

0001 Biological continuity relies on successful cell division. Research over the years has provided a good understanding of how cells divide to form two daughter cells through mitosis. During mitosis, chromosomes are duplicated and divied up between the cells to provide each daughter cell with a complete copy of the organism’s genome. The cell, however, doesn’t contain only genomic DNA but can ...

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Cellular Allometry: The Spindle in Development and Inheritance

Recent studies have demonstrated a correlation between cell size and the behaviors of the cytoskeletal division machinery during embryogenesis, giving insight into how a core cellular process is modulated over the course of development.

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Chromatin inheritance upon Zeste-mediated Brahma recruitment at a minimal cellular memory module.

Polycomb group and trithorax group proteins maintain the memory of repressed and active chromatin states by regulating chromatin of their target genes via DNA sequences termed Polycomb- and trithorax response elements. Since these elements often overlap and are able to convey the memory of both silent and active chromatin through cell division, they were also defined as cellular memory modules ...

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Asymmetrical Inheritance of Plasmids Depends on Dynamic Cellular Geometry and Volume Exclusion Effects

The asymmetrical inheritance of plasmid DNA, as well as other cellular components, has been shown to be involved in replicative aging. In Saccharomyces cerevisiae, there is an ongoing debate regarding the mechanisms underlying this important asymmetry. Currently proposed models suggest it is established via diffusion, but differ on whether a diffusion barrier is necessary or not. However, no st...

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Mitochondrial DNA Mutations, Pathogenicity and Inheritance

Mitochondria contain their own DNA (mtDNA), which codes for 13 proteins (all subunits of the respiratory chain complexes), 22 tRNAs and 2 rRNAs. Several mtDNA point mutations as well as deletions have been shown to be causative in well-defined mitochondrial disorders. A mixture of mutated and wild type mtDNA (heteroplasmy) is found in most of these disorders. Inheritance of mtDNA is maternal, a...

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ژورنال

عنوان ژورنال: PLoS Biology

سال: 2006

ISSN: 1545-7885

DOI: 10.1371/journal.pbio.0040446