Cellular Cytotoxicity of Antiglaucoma Drugs in Cultured Corneal Endothelial Cells
نویسندگان
چکیده
منابع مشابه
Toxicity of antiglaucoma drugs with and without benzalkonium chloride to cultured human corneal endothelial cells
PURPOSE The toxicity of antiglaucoma medications to ocular surface cells has been evaluated extensively; however, the toxicity to corneal endothelial cells (CECs) remains elusive. Our aim is to evaluate the toxicity of antiglaucoma medications to CECs using an in vitro toxicity assay. METHODS Primary cultures of human (H) CECs derived from eye bank specimens were established. Following exposu...
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BACKGROUND Intraocular cytomegalovirus (CMV) infections, including endotheliitis and retinitis, have been reported to threaten the host's vision. These infections have been treated with systemic or intravitreal GCV injection. Intracameral GCV injection can be an effective treatment option that avoids systemic side effects. The cytotoxic effect of ganciclovir (GCV) on cultured human corneal endo...
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Proparacaine is a widely used topical anesthetic in ophthalmic optometry and surgery, and has been reported to have cytotoxic effects on rabbit corneal endothelial cells after prolonged and repeated usage. Since rabbit is an exceptive mammal whose corneal endothelial cells still maintaining proliferation abilities even in adulthood, whether proparacaine has cytotoxic effects on human corneal en...
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PURPOSE Previous studies have indicated that improper use of mitomycin C (MMC) caused cytotoxicity in corneal endothelial cells. The aim of the present study was to investigate whether MMC induces cellular apoptosis in corneal endothelial cells and to determine the mechanism by which this may occur. METHODS Porcine corneal endothelial cells were acquired from primary culture. Cellular damage ...
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ژورنال
عنوان ژورنال: The Kaohsiung Journal of Medical Sciences
سال: 2007
ISSN: 1607-551X
DOI: 10.1016/s1607-551x(09)70384-5