Cell Vacuolation, a Manifestation of the El Tor Hemolysin of Vibrio cholerae
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چکیده
منابع مشابه
Cell vacuolation, a manifestation of the El tor hemolysin of Vibrio cholerae.
Culture supernatants of nontoxigenic nonepidemic clinical strains of Vibrio cholerae belonging to diverse serogroups were found to induce vacuolation of nonconfluent HeLa cells. The vacuoles became prominent 18 h after introduction of culture supernatant, and vacuolated cells survived for 48 h and then died. Only a fraction of the vacuolated cells took up neutral red dye, implying that there we...
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To the Editor: The traditional causative agent of cholera, Vibrio chol-erae O1, has 2 biotypes, classical and El Tor. The current seventh pandemic that began in 1961 and has spread to much of the world is caused by the El Tor biotype. This biotype has replaced the classical biotype responsible for the previous pandemics. The classical and El Tor biotypes are differentiated by phenotypic tests (...
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Antibiotic treatment does not play a major role in the management of patients with cholera where fluids and electrolytes replacement have been the mainstay of treatment. Nevertheless, antibiotics do lessen the duration of the diarrhoea and shorten the period of excretion of the pathogen. In Malaysia, tetracycline is the drug of choice for cholera infection. It is also given to contacts of confi...
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The enterotoxicity of an El Tor-like hemolysin purified from non-O1 Vibrio cholerae was investigated. Fluid accumulation was induced by injection of purified hemolysin into the ligated intestinal loops in adult rabbits (De test), intraintestinal administration in infant rabbits (Dutta test), and oral inoculation in suckling mice. The accumulated fluid was invariably mucous and bloody, and a his...
متن کاملDetermination of ctxAB expression in Vibrio cholerae Classical and El Tor strains using Real-Time PCR
Cholera is an infection of the small intestines caused by the bacterium V. cholerae. It is a major cause of health threat and also a major cause of death worldwide and especially in developing countries. The major virulence factor produced by V. cholerae during infection is the cholera toxin. Total mRNA extraction and reverse transcription was performed for making ctxAB cDNA. Relative Real-Time...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 2000
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.68.4.1928-1933.2000