منابع مشابه
Cell kinetic analysis of brain tumors using the monoclonal antibody Ki-67: in vitro and in situ study.
Ki-67 is a commercially available mouse monoclonal antibody (MoAb), which reacts with a nucleolar antigen (the Ki-67 antigen) expressed in proliferating eukaryotic cells. The author examined the precise localization of the Ki-67 antigen in C-6 cells using immunohistochemical and immunoelectron microscopic methods and estimated the proliferative activity of human brain tumors in situ. Positive n...
متن کاملBromodeoxyuridine in tumors and chromosomes detected with a monoclonal antibody.
Using a monoclonal antibody to bromodeoxyuridine (BUdR) and immunohistochemistry, we measured the incorporation of this thymidine analogue into the DNA of human normal and malignant cells exposed in vivo. BUdR given as a constant intravenous infusion for 12 or 24 h daily for up to 13 d resulted in a steady-state plasma level of 10(-6) M during the infusion. We demonstrated extensive incorporati...
متن کاملIdentification of a cancer stem cell in human brain tumors.
Most current research on human brain tumors is focused on the molecular and cellular analysis of the bulk tumor mass. However, there is overwhelming evidence in some malignancies that the tumor clone is heterogeneous with respect to proliferation and differentiation. In human leukemia, the tumor clone is organized as a hierarchy that originates from rare leukemic stem cells that possess extensi...
متن کاملEvaluation of Diagnostic Value of CT Scan and MRI in Brain Tumors and Comparison with Biopsy
Abstract Background Cerebral neoplasm arises from brain, spinal cord and meningeal cells. Not only malignant cerebral neoplasm also benign tumor could lead to death due to mass effect on vital structures. Access to these tumors is difficult, and MRI and CT scan could be helpful in determining anatomical location of tumors and distinction of malignant from benign. Objective For better and ea...
متن کاملKinetic studies of the brain hexokinase reaction.
The mechanism of the hexokinase reaction has been the subject of numerous investigations in recent years (l-5). ijgren and Engstrijm reported the incorporation of Pa from labeled adenosine triphosphate (ATP) into the phosphoserine moiety of hexokinase in the absence of substrate glucose and concluded that an enzyme-phosphate intermediate participated in the reaction (2). Gamble and Najjar, howe...
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ژورنال
عنوان ژورنال: Cytometry
سال: 1985
ISSN: 0196-4763,1097-0320
DOI: 10.1002/cyto.990060619