Cell-instructive high-resolution micropatterned polylactic acid surfaces
نویسندگان
چکیده
منابع مشابه
Development of micropatterned cell-sensing surfaces.
Microfabricated surfaces have been widely utilized for defining adhesion of single cells or groups of cells of various kinds. Beyond simple control of cell attachment, it is often important to monitor the molecules released by cells. Co-immobilizing miniature sensors alongside cells enables more sensitive detection of secreted factors and may allow for such detection to happen within the contex...
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Cancer invasion and progression involves a motile cell phenotype, which is under complex regulation by growth factors/cytokines and extracellular matrix (ECM) components within the tumor microenvironment. Hyaluronic acid (HA) is one stromal ECM component that is known to facilitate tumor progression by enhancing invasion, growth, and angiogenesis(1). Interaction of HA with its cell surface rece...
متن کاملMammalian cell cultures on micropatterned surfaces of weak-acid, polyelectrolyte hyperbranched thin films on gold.
A four-step soft lithographic process based on micro-contact printing of organic monolayers, hyperbranched polymer grafting, and subsequent polymer functionalization results in polymer/n-alkanethiol patterns that direct the growth and migration of mammalian cells. The functional units on these surfaces are three-dimensional cell "corrals" that have walls 52+/-2 nm in height and lateral dimensio...
متن کاملPolylactic acid (PLA)
This website provides an excellent overview of PLA as a polymer, its properties, and manufacture. This web article describes the production of lactic acid from biomass by microbial fermentation coupled to a poly-merization process to make PLA. The article is a bit dated and its industrial projections are now seen to be a bit over-optimistic. NatureWorks is the company that started large-scale p...
متن کاملDegradation of Micropatterned Surfaces by Cell-Dependent and -Independent Processes†
This paper describes a study to determine the role of active cellular processes in the initial patterning and eventual degradation of different micropatterned substrates. We compared the effects of serum and cell type on the ability of cells to crawl onto the nonadhesive regions of a variety of patterned substrates. Cells initially patterned in the presence of serum onto substrates manufactured...
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ژورنال
عنوان ژورنال: Biofabrication
سال: 2017
ISSN: 1758-5090
DOI: 10.1088/1758-5090/aa7d24