Cell-Free RNA Is a Reliable Fetoplacental Marker in Noninvasive Fetal Sex Determination
نویسندگان
چکیده
منابع مشابه
Cell-Free RNA Is a Reliable Fetoplacental Marker in Noninvasive Fetal Sex Determination.
BACKGROUND Noninvasive genetic tests that use cell-free fetal DNA (cffDNA) are used increasingly in prenatal care. A low amount of cffDNA can have detrimental effects on the reliability of these tests. A marker to confirm the presence of fetal nucleic acids is therefore required that is universally applicable and easy to incorporate. METHODS We developed a novel multiplex, single-tube, noninv...
متن کاملNoninvasive fetal RHD genotyping using cell-free fetal DNA incorporating fetal RASSF1A marker in RhD-negative pregnant women in Korea
risk of HDFN, which can cause fetal anemia, hydrops, and intrauterine fetal death. Babies born with HDFN are at significant risk of neonatal morbidity and mortality [1,2]. Prenatal detection of the fetal RhD status in a pregnant woman with RhD-negative provides useful information for predicting the risk of HDFN and Noninvasive fetal RHD genotyping using cell-free fetal DNA incorporating fetal R...
متن کاملearly non-invasive determination of fetal sex using cell-free dna
the first step in the prenatal diagnosis of x-linked genetic disorders is determining fetus gender. current invasive methods to obtain the dna source of the fetus instead of its miscarriage risk, has harmful stress for high risk pregnancies. cell free fetal dna (cffdna) circulating in the maternal blood, has now become a useful source of noninvasive prenatal diagnosis. considering limitation of...
متن کاملNapsin-A Expression, a Reliable Immunohistochemical Marker for Diagnosis of Ovarian and Endometrial Clear Cell Carcinomas
Background & Objective: Clear cell carcinomas (CCC) differ from other types of ovarian and endometrial carcinomas in biolo...
متن کاملEvaluation of Sample Stability and Automated DNA Extraction for Fetal Sex Determination Using Cell-Free Fetal DNA in Maternal Plasma
OBJECTIVE The detection of paternally inherited sequences in maternal plasma, such as the SRY gene for fetal sexing or RHD for fetal blood group genotyping, is becoming part of daily routine in diagnostic laboratories. Due to the low percentage of fetal DNA, it is crucial to ensure sample stability and the efficiency of DNA extraction. We evaluated blood stability at 4°C for at least 24 hours a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 2015
ISSN: 0009-9147,1530-8561
DOI: 10.1373/clinchem.2015.244962