Cell-free, quantitative mineralization measurements as a proxy to identify osteoinductive bone graft substitutes
نویسندگان
چکیده
منابع مشابه
Bone-grafting and bone-graft substitutes.
Bone grafts are often necessary to provide support, fill voids, and enhance biologic repair of skeletal defects. Autogenous bone recovered from the patient’s own iliac crest is generally considered the gold standard of bone grafts. There is a need for alternatives, however, because of limited autograft quantities, donor site morbidity, and other problems including limited biologic performance. ...
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Treatment of delayed union, malunion, and nonunion is a challenge to the orthopaedic surgeons in veterinary and human fields. Apart from restoration of alignment and stable fixation, in many cases adjunctive measures such as bone-grafting or use of bone-graft substitutes are of paramount importance. Bone-graft materials usually have one or more components: an osteoconductive matrix, which acts ...
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We have synthesized calcium phosphate-based, strontium (Sr) containing, porous ceramic granules for use as bone graft substitutes. The granules with a particle size between 1 and 2 mm and a (macro)-pore size around 200–500μm were mixed with a fibrin sealant to form a moldable composite material. The starting material with Sr contents between 0 and 100% Sr were precipitated from Ca/Sr solutions ...
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Synthetic bone graft substitutes have evolved in response to the downsides of autograft and allograft. This article consolidates the literature regarding the use of mineral bone graft substitutes in the treatment of cavitary bone defects. No level I studies regarding their use in the treatment of bone tumors have been performed, but the clinical studies that have been published indicate that ca...
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Autogenous bone grafts from the iliac crest have long been the gold standard for repair and reconstruction of bone; however harvesting of the grafts from the iliac crest is associated with donor site morbidity, particularly chronic pain. The bone morphogenetic proteins (BMPs) are soluble bone matrix glycoproteins that induce the differentiation of osteoprogenitor cells into osteogenic cells and...
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ژورنال
عنوان ژورنال: Biomaterials
سال: 2021
ISSN: 0142-9612
DOI: 10.1016/j.biomaterials.2021.120912