Cell-free DNA vs sequential screening for the detection of fetal chromosomal abnormalities
نویسندگان
چکیده
منابع مشابه
Screening for Fetal Chromosomal Abnormalities
This Practice Bulletin was developed by the ACOG Committee on Practice Bulletins—Obstetrics, the ACOG Committee on Genetics, and the Society for Maternal–Fetal Medicine Publications Committee with the assistance of Ray Bahado-Singh, MD, and Deborah Driscoll, MD. The information is designed to aid practitioners in making decisions about appropriate obstetric and gynecologic care. These guideline...
متن کاملScreening for Fetal Chromosomal Abnormalities
This Practice Bulletin was developed by the ACOG Committee on Practice Bulletins—Obstetrics, the ACOG Com mittee on Genetics, and the Society for Maternal–Fetal Medicine Publications Com mit tee with the assistance of Ray Bahado-Singh, MD, and Deborah Driscoll, MD. The in for ma tion is de signed to aid practitioners in making decisions about appropriate obstetric and gyneco logic care. These g...
متن کاملOptimal detection of fetal chromosomal abnormalities by massively parallel DNA sequencing of cell-free fetal DNA from maternal blood.
BACKGROUND Massively parallel DNA sequencing of cell-free fetal DNA from maternal blood can detect fetal chromosomal abnormalities. Although existing algorithms focus on the detection of fetal trisomy 21 (T21), these same algorithms have difficulty detecting trisomy 18 (T18). METHODS Blood samples were collected from 1014 patients at 13 US clinic locations before they underwent an invasive pr...
متن کاملIntroducing a New and Simple Protocol for Capillary Electrophoresis of Cell Free Fetal Double Stranded DNA
Isolation of cell free fetal DNA (cffDNA) from maternal serum usually leads to very low concentrations of DNA impeding further resolving through conventional methods of electrophoresis. Although several protocols have been described for capillary electrophoresis (CE) of double stranded DNA, they usually need using special polymers or coated capillaries which degrade over time. Herein, we propos...
متن کاملAssociation of Fetal and Parental Chromosomal Abnormalities with Congenital Anomalies
Background & Aims: Chromosome abnormalities are a major cause of miscarriage and neonatal mortality. The present study aimed to determine the association of fetal and parents chromosomal abnormalities with congenital anomalies. Methods: A cross-sectional study was performed in a tertiary referral center (Afzalipour Hospital) over 16 months period (2011-2012). The study groups consisted of 77 fe...
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ژورنال
عنوان ژورنال: American Journal of Obstetrics and Gynecology
سال: 2016
ISSN: 0002-9378
DOI: 10.1016/j.ajog.2015.12.018