منابع مشابه
Cell-ECM interactions control DDR
Fundamental to an improvement of cancer cure rates is a better understanding of the underlying molecular mechanisms driving resistance to standard treatments such as radioand chemotherapy. A powerful and promising approach to sensitize cancer cells to therapy is represented by Paul Ehrlich ́s old and still up-to-date concept of the “magic bullet”. Reviewing the complexity of the “hallmarks of ca...
متن کاملDental Cell-ECM Interactions in Tooth Tissue Regeneration
Introduction Tooth loss remains a significant health problem even in developed countries such as the United States. Our research focuses on the development of non-synthetic, bioengineered materials for dental and craniofacial tissue engineering. We hypothesize that dental stem cells harvested from extracted teeth provides a potential source for human progenitor cells for tissue engineering. Our...
متن کاملMCF-10A-NeoST: a new cell system for studying cell-ECM and cell-cell interactions in breast cancer.
PURPOSE There is a continuing need for genetically matched cell systems to model cellular behaviors that are frequently observed in aggressive breast cancers. EXPERIMENTAL DESIGN We report here the isolation and initial characterization of a spontaneously arising variant of MCF-10A cells, NeoST, which provides a new model to study cell adhesion and signal transduction in breast cancer. RESU...
متن کاملHuman trophoblast-extracellular matrix (ECM) interactions in vitro: ECM thickness modulates morphology and proteolytic activity.
Trophoblast invasion of the uterine extracellular matrix, a critical process for human implantation and uteroplacental vascular development, is a striking example of controlled invasiveness. To examine cellular behavior relevant to this process, human trophoblasts were cultured on (i) Millicell filters prelayered with Matrigel and (ii) coverslips precoated with a gentle slope of Matrigel (Matri...
متن کاملJapanese Passives as Control/Raising/ECM
Japanese has three passives, Direct (1), Niyotte (2), and Indirect (3), which show different syntactic and semantic characteristics (Hoshi 1999). In this paper, I propose an analysis of Japanese passives as verbs instantiating three types of non-finite complementation: control, raising, and ECM, and argue that the proposed analysis provides a principled account for them. Previous studies have i...
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ژورنال
عنوان ژورنال: Oncoscience
سال: 2015
ISSN: 2331-4737
DOI: 10.18632/oncoscience.184