منابع مشابه
Cell death and adenosine triphosphate: the paradox.
The inhibition of cell death lies at the heart of the interesting publication in this issue of Circulation by Huang et al.1 The authors’ major message is that Bcl-xL gene transfer prolongs the cold preservation time of rat hearts destined for transplantation. Bcl-xL belongs to the large Bcl-2 family and has been reported to inhibit Bax translocation to the mitochondria and to reduce cytochrome ...
متن کاملAdenosine triphosphate-induced photoreceptor death and retinal remodeling in rats
Many common causes of blindness involve the death of retinal photoreceptors, followed by progressive inner retinal cell remodeling. For an inducible model of retinal degeneration to be useful, it must recapitulate these changes. Intravitreal administration of adenosine triphosphate (ATP) has recently been found to induce acute photoreceptor death. The aim of this study was to characterize the c...
متن کاملP2 receptor antagonist trinitrophenyl-adenosine-triphosphate protects hippocampus from oxygen and glucose deprivation cell death.
In this work, we mainly used the organotypic model of rat hippocampus to demonstrate the protective role of the P2 receptor antagonist trinitrophenyl-adenosine-triphosphate (TNP-ATP) during oxygen/glucose deprivation. Among the P2X receptors that TNP-ATP specifically blocks, mainly P2X1 seems to be involved in the processes of cell damage after oxygen/glucose deprivation. P2X1 receptor is stron...
متن کاملAdenosine triphosphate inhibition in myosin adenosine triphosphate systems.
Factors affecting inhibition of myosin ATPase by ATP, such as concentration of the enzyme, of ATP, and of the divalent metals, calcium and magnesium, have been studied and the results are reported here. Experiments were carried out under conditions in which no known magnesium effects occurred, so that only the effect of calcium on the nucleoside triphosphatase activity of myosin A could be qual...
متن کاملComputerized modeling of adenosine triphosphate, adenosine triarsenate and adenosine trivanadate.
Computerized molecular models of adenosine triphosphate, adenosine tri-arsenate and adenosine trivanadate have been generated using the molecular mechanics technique. The analysis of structural parameters indicated that, at least theoretically, adenosine triarsenate is a realistic candidate for replacement of adenosine triphosphate in biochemical pathways. On the contrary, the structural arrang...
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ژورنال
عنوان ژورنال: Circulation
سال: 2005
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.105.551846