Cell cycle regulatory markers as potential prognostic biomarkers in uterine carcinosarcoma

The relevance of cell cycle regulatory markers with uterine carcinosarcoma was investigated. immunohistochemical expression p16, p53, and cyclin D1 were assessed using tissue microarray 55 eligible patients. p16 p53 showed a high rate strong (+3) immune reaction in carcinomatous/sarcomatous components (61.8%/70.9% 52.7%/56.4%, respectively). Cyclin 14.5%/7.3%of the components. Strong related to higher recurrence, lymph node metastasis, bigger tumor size. lower International Federation Gynecology Obstetrics (FIGO) stage recurrence rate. In univariate regression analysis, FIGO stage, prognostic factors for disease-free survival. disease specific multivariate carcinomatous component independent survival (odds ratio (OR), 95% confidence interval (CI); 3.2 (1.1–9.6) 3.5 (1.3–9.7); p = 0.035 0.017). predictor size, outcome carcinosarcoma.