Cell Alignment Modulated by Surface Nano-Topography – Roles of Cell-Matrix and Cell-Cell Interactions

Cell alignment is critical in numerous areas, from tissue engineering to biohybrid robotics. modulated through many features including surface topographies, mechanical cues cell-matrix interactions, and cell-cell interactions. In this study, we present our approach examine the role of topographies interactions with respect cell alignment. We developed an create wavy at nanometer size scale, which when integrated culture affects Within a defined range wavelengths amplitudes dependent on confluency. This alignment’s dependence confluency suggests that related may be correlated Thus, inhibited N-cadherin introduced anti-N-cadherin while culturing cells controlled topographies. found using anti-N-cadherin, patterned surfaces required greater achieve same not presence antibody. Our results will important areas repair, differentiation, systems.