Celastrus paniculatus and memantine prevent alcohol dependence and improve decision making in alcohol dependent C57BL6 mice

Background: Alcohol use disorder poses a huge burden with only handful of approved drugs. AUD is associated impaired decision-making that leads to compulsive drinking despite negative consequences. A drug decreases alcohol consumption as well improves may thus prove more useful. This study was planned evaluate the effect two drugs, Celastrus paniculatus and memantine on preference decision impairment in alcohol-dependent mice. Methods: In part 1, both drugs studied using intermittent access model 70 male C57BL6 2, making rodent version Iowa gambling task. Mice were divided seven groups: Group 1-3: (140, 280, 560 mg/kg), 4: (25 5: vehicle control 1 (Milk), 6: 2 (normal saline) 7: naltrexone(1mg/kg). Results: Percentage lower test groups i.e., at medium (40.90±15.18%) high doses (31.79±7.46%) vs. milk (82.74±8.53%; p<0.05); group (36.28±10.99%) normal saline (83.27±5.51%; p<0.05). The results not significantly different Naltrexone (19.70±6.90%). disadvantageous arms also paniculatus, (50.52±1.92%) (48.11±2.43%) compared (54.47±2.73%; p<0.05) (47.45±1.67%) (54.00±2.73%; p<0.05), indicating better ability groups. findings comparable (45.43±2.52%). Conclusions: These indicate reduce improve