Cdc42 Mediates Cancer Cell Chemotaxis in Perineural Invasion
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چکیده
منابع مشابه
Neurotransmitter substance P mediates pancreatic cancer perineural invasion via NK-1R in cancer cells.
Pancreatic cancer significantly affects the quality of life due to the severe abdominal pain. However, the underlying mechanism is not clear. This study aimed to determine the relationship between Substance P (SP) and pancreatic cancer perineural invasion (PNI) as well as the mechanism of SP mediating pancreatic cancer PNI, which causes pain in patients with pancreatic cancer. Human pancreatic ...
متن کاملSignal Transduction Neurotransmitter Substance P Mediates Pancreatic Cancer Perineural Invasion via NK-1R in Cancer Cells
Pancreatic cancer significantly affects the quality of life due to the severe abdominal pain. However, the underlying mechanism is not clear. This study aimed to determine the relationship between Substance P (SP) and pancreatic cancer perineural invasion (PNI) as well as themechanism of SPmediating pancreatic cancer PNI, which causes pain in patients with pancreatic cancer. Human pancreatic ca...
متن کاملThe chemokine (CCL2-CCR2) signaling axis mediates perineural invasion.
UNLABELLED Perineural invasion is a form of cancer progression where cancer cells invade along nerves. This behavior is associated with poor clinical outcomes; therefore, it is critical to identify novel ligand-receptor interactions between nerves and cancer cells that support the process of perineural invasion. A proteomic profiler chemokine array was used to screen for nerve-derived factors s...
متن کاملAssociation of diabetes and perineural invasion in pancreatic cancer
Diabetes and perineural invasion are frequently observed in pancreatic cancer. In this study, we tested possible relations between diabetes and perineural invasion in patients with resected pancreatic cancer. We conducted a retrospective study in 544 cases of resected pancreatic adenocarcinoma seen at the University of Texas MD Anderson Cancer Center during 1996-2011. Information on tumor chara...
متن کاملPerineural Invasion and Risk of Lethal Prostate Cancer.
Background: Prostate cancer has a propensity to invade and grow along nerves, a phenomenon called perineural invasion (PNI). Recent studies suggest that the presence of PNI in prostate cancer has been associated with cancer aggressiveness.Methods: We investigated the association between PNI and lethal prostate cancer in untreated and treated prostate cancer cohorts: the Swedish Watchful Waiting...
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ژورنال
عنوان ژورنال: Molecular Cancer Research
سال: 2020
ISSN: 1541-7786,1557-3125
DOI: 10.1158/1541-7786.mcr-19-0726