CD4+CD25+ Immunoregulatory T Cells

CD4+CD25+ Immunoregulatory T Cells

CD4(+)CD25(+) immunoregulatory T cells play a pivotal role in preventing organ-specific autoimmune diseases and in tolerance induction to allogeneic organ transplants. We investigated whether these cells could also control graft-versus-host disease (GVHD), the main complication after allogeneic hematopoietic stem cell transplantation (HSCT). Here, we show that the few CD4(+)CD25(+) T cells natu...

CD4CD25 Regulatory T Cells Preventing Detrimental Autoimmune Reactions

Objective: Autoimmune diseases will occur when the immune response inflicts damage to tissues in the body. Attempts to overcome this disease have a lot to do but they have not yielded satisfying results. In this study, the function of CD4CD25 regulatory T cells was evaluated for therapeutic potential to prevent the development of autoreactive T

Immunoregulatory T Cells Is Antigen Nonspecific

CD4CD25 Regulatory Cells in Human Peripheral Blood

Thymectomy in mice on neonatal day 3 leads to the development of multiorgan autoimmune disease due to loss of a CDCD25 T cell regulatory population in their peripheral lymphoid tissues. Here, we report the identification of a CD4 population of regulatory T cells in the circulation of humans expressing high levels of CD25 that exhibit in vitro characteristics identical with those of the CD4CD25 ...

CD4CD25 regulatory T cells and CD4CD69 T cells in peripheral blood of patients with cutaneous lupus erythematosus

Lupus erythematosus (LE) is a chronic autoimmune disease characterized by functional alterations of T and B lymphocyte subsets. The cutaneous forms of lupus erythematosus comprise subacute cutaneous LE (SCLE) and discoid LE (DLE). Recent studies have shown that the activation process of lymphocytes in patients with systemic disease manifestations is disturbed. The aim of this study was to inves...