CD133 expression in osteosarcoma and derivation of CD133+ cells

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CD133 Expression and Identification of CD133/nestin Positive Cells in Rhabdomyosarcomas and Rhabdomyosarcoma Cell Lines

BACKGROUND Co-expression of CD133, cell surface glycoprotein, and nestin, an intermediate filament protein, was determined to be a marker of neural stem cells and of cancer stem cells in neurogenic tumors. METHODS We examined the expression of CD133 and nestin in ten tumor tissue samples taken from patients with rhabdomyosarcomas and in five rhabdomyosarcoma cell lines. Immunohistochemistry a...

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Expression of CD133 in endometrial cancer cells and its implications

Cancer stem cells are an attractive therapeutic target for cancer. The present study examined stem cell characteristics of CD133+ cells isolated from endometrial cancer. Phenotypic characteristics, proliferation, migration, anchorage-independent growth, chemoresistance, gene expression profile and tumorigenicity of CD133+ tumor cells were assessed. Primary tumor exhibited immunoreactivity for C...

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characterization of megakaryocyte progenitor cells differentiated from umbilical cord blood cd133+ and cd133– cells

objective: this study was performed to determine the immunophenotype of megakaryocyte progenitor cells differentiated from ucb cd133+ and cd133− cells under the effects of interleukin–3 (il–3), interleukin–6 (il–6), stem cell factor (scf) and thrombopoietin (tpo) in vitro. materials and methods: cd133+and cd133− cells were isolated by using cd133 isolation kit following the manufacturer’s instr...

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Poly(lactic-co-glycolic acid) nanoparticles conjugated with CD133 aptamers for targeted salinomycin delivery to CD133+ osteosarcoma cancer stem cells

BACKGROUND Cancer stem cells (CSCs) possess the characteristics associated with normal stem cells and are responsible for cancer initiation, recurrence, and metastasis. CD133 is regarded as a CSCs marker of osteosarcoma, which is the most common primary bone malignancy in childhood and adolescence. Salinomycin, a polyether ionophore antibiotic, has been shown to kill various CSCs, including ost...

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ژورنال

عنوان ژورنال: Molecular Medicine Reports

سال: 2012

ISSN: 1791-2997,1791-3004

DOI: 10.3892/mmr.2012.1231