CD107a+ (LAMP-1) Cytotoxic CD8+ T-Cells in Lupus Nephritis Patients

Cytotoxic CD8 + T-cells play a pivotal role in the pathogenesis of systemic lupus erythematosus (SLE). The aim this study was to investigate CD107a (LAMP-1) on cytotoxic SLE-patients particular with nephritis. Peripheral blood ( n = 31) and healthy controls 21) analyzed for expression CD314 by flow cytometry. Kidney biopsies nephritis patients were investigated presence C107a cells immunohistochemistry immunofluorescence staining. percentages significantly decreased as compared (40.2 ± 18.5% vs. 47.9 15.0%, p 0.02). This even more significant inactive disease. There correlation between SLEDAI. evaluation showed number mainly located peritubular infiltrates. intrarenal correlated proteinuria. These results demonstrate that have an altered which seems be associated disease activity. proof suggests