CCR5 Promoter Alleles and Specific DNA Binding Factors
نویسندگان
چکیده
منابع مشابه
CCR5 promoter alleles and specific DNA binding factors.
At least 12 single nucleotide polymorphisms (SNPs) within the 59 upstream regulatory region of the human CCR5 chemokine and HIV-1 receptor gene have been described (1–4). Our recent report (1) and others (2) have shown that a common 10-SNP allele haplotype, CCR5P1, with demonstrated promoter activity (5) confers relatively rapid progression to various AIDS end points in a genetic epidemiologic ...
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Evidence showed that chemokines serve as pro-migratory factors for immune cells. CCL3, CCL4 and CCL5, as the main CC chemokines subfamily members, activate immune cells through binding to CC chemokine receptor 5 or CCR5. Macrophages, NK cells and T lymphocytes express CCR5 and thus, affected CCR5 expression or functions could be associated with altered immune responses. Deletion of 32 base pai...
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The transcription of many genes, particularly in prokaryotes, is controlled by transcription factors whose activity can be modulated by controlling their DNA binding affinity. Understanding the molecular mechanisms by which DNA binding affinity is regulated is important, but because forming definitive conclusions usually requires detailed structural information in combination with data from ext...
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متن کاملthe frequency of ccr5 promoter polymorphisms and ccr5 32 mutation in iranian populations
evidence showed that chemokines serve as pro-migratory factors for immune cells. ccl3, ccl4 and ccl5, as the main cc chemokines subfamily members, activate immune cells through binding to cc chemokine receptor 5 or ccr5. macrophages, nk cells and t lymphocytes express ccr5 and thus, affected ccr5 expression or functions could be associated with altered immune responses. deletion of 32 base pai...
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ژورنال
عنوان ژورنال: Science
سال: 1999
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.284.5412.223a