C–C Bond Forming Reactions Enabled by Vitamin B₁₂?Opportunities and Challenges

Cobalt not only is an essential micronutrient for mammals but also marks itself as important in organic synthesis, especially the field of catalysis. Various useful reactions, such alkene hydroformylation, hydrogenation, heterofunctionalizations carbon–carbon double bonds, C–H activation, and cross-coupling have been realized with aid this metal. At same time, cobalt deserves special attention a catalyst radical processes; fact, form vitamin B12, it was designed by Nature reversible carrier radicals. Since molecule native Co-complex, very attractive development sustainable transformations, has already demonstrated that B12 its derivatives mediate numerous reactions found applications both construction complex molecules degradation polyhalogenated pollutants. However, Perspective, we focus readers’ on C–C bond forming catalyzed which are particularly tool synthesis greener manner. We ponder over challenges remain to be addressed solutions expected come.