Caveolin-1: Would-be Achilles’ heel of tumor microenvironment?

Tumor cell metabolism: cancer's Achilles' heel.

The essential hallmarks of cancer are intertwined with an altered cancer cell-intrinsic metabolism, either as a consequence or as a cause. As an example, the resistance of cancer mitochondria against apoptosis-associated permeabilization and the altered contribution of these organelles to metabolism are closely related. Similarly, the constitutive activation of signaling cascades that stimulate...

The Achilles' Heel of O(3, 1)?

What's the best way to represent an isometry of hyperbolic 3-space H 3 ? Geometers traditionally worked in SL(2, C), but for software development many now prefer the Minkowski space model of H 3 and the orthogonal group O(3, 1). One powerful advantage is that ideas and computations in S 3 using matrices in O(4) carry over directly to H 3 and O(3, 1). Furthermore, O(3, 1) handles orientation rev...

Cancer's new Achilles' heel?

Claims to the discovery of cancers Achilles’ heel are multiple, even clichéd. Analogies to this Greek myth usually refer to the fall of the undefeatable, yet the novelty behind the legend is that a seemingly immortal foe could be toppled by something so innocuous as his heel. This may be the case for cancer and a non-coding mitochondrial RNA that as yet has no known physiological function or me...

Ideology: Criminology's Achilles' Heel?

The Achilles ’ Heel of CyberDefense