منابع مشابه
Caveolae: where incoming and outgoing messengers meet.
Plasmalemmal caveolae were first identified as an endocytic compartment in endothelial cells, where they appear to move molecules across the cell by transcytosis. More recently, they have been found to be sites where small molecules are concentrated and internalized by a process called potocytosis. A growing body of biochemical and morphological evidence indicates that a variety of molecules kn...
متن کاملCaveolae
few key dynamic shapes, or as some physicists say, universal patterns. Highly aligned groups, rotating mills and dynamic figure-of-eights are key examples. These types of patterns are observed not only in moving animal groups, but also in cell migration, bacteria populations, and even in many physical and chemical systems. The question is whether a few key mechanisms could explain similarities ...
متن کاملDelivery of ligands from sorting endosomes to late endosomes occurs by maturation of sorting endosomes
After endocytosis, lysosomally targeted ligands pass through a series of endosomal compartments. The endocytic apparatus that accomplishes this passage may be considered to take one of two forms: (a) a system in which lysosomally targeted ligands pass through preexisting, long-lived early sorting endosomes and are then selectively transported to long-lived late endosomes in carrier vesicles, or...
متن کاملRecycling endosomes
Heparin sustains the brain myloid plaque formation can be inhibited by an unlikely culprit, according to work by Scholefield et al. on page 97. The group finds that heparan sulfate (HS)—normally a part of the cell surface and extracellular matrix—functions in cells to slow the production of the plaque components of Alzheimer's disease. Amyloid plaques are aggregates of the amyloid -peptide (A ...
متن کاملRegulated internalization of caveolae
Caveolae are specialized invaginations of the plasma membrane which have been proposed to play a role in diverse cellular processes such as endocytosis and signal transduction. We have developed an assay to determine the fraction of internal versus plasma membrane caveolae. The GPI-anchored protein, alkaline phosphatase, was clustered in caveolae after antibody-induced crosslinking at low tempe...
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ژورنال
عنوان ژورنال: Developmental Cell
سال: 2004
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2004.09.009