Causes and Consequences of Lung Cancer Heterogeneity

Lung cancer is the foremost cause of related deaths in U.S. The relatively poor outcome lung patients stems from fact that tumor not considered context its microenvironment while treating patients. a heterogeneous disease composed genetically and phenotypically different cells as well constantly interact with each other. Currently, treatment guided by genetic alterations identified specimen, which representative whole tumor. Genome wide studies patient derived tumors suggest presence significantly high numbers single Epigenetic variations, such DNA methylation, histone modifications microRNAs, have also been suggested to play role heterogeneity. Such cellular variations lead differential interactions between therefore evolving. In order gain better understanding progression design effective strategies, studying becomes very important.