Cationic host defense peptides; novel antimicrobial therapeutics against Category A pathogens and emerging infections
نویسندگان
چکیده
منابع مشابه
Cationic host defense (antimicrobial) peptides.
Members of the cationic host defense (antimicrobial) peptide family are widely distributed in nature, existing in organisms from insects to plants to mammals and non-mammalian vertebrates. Although many demonstrate direct antimicrobial activity against bacteria, fungi, eukaryotic parasites and/or viruses, it has been established that cationic peptides have a key modulatory role in the innate im...
متن کاملImmune modulation by multifaceted cationic host defense (antimicrobial) peptides.
Cationic host defense (antimicrobial) peptides were originally studied for their direct antimicrobial activities. They have since been found to exhibit multifaceted immunomodulatory activities, including profound anti-infective and selective anti-inflammatory properties, as well as adjuvant and wound-healing activities in animal models. These biological properties suggest that host defense pept...
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One component of host defense at mucosal surfaces seems to be epithelium-derived antimicrobial peptides. Antimicrobial peptides are classified on the basis of their structure and amino acid motifs. Peptides of the defensin, cathelicidin, and histatin classes are found in humans. In the airways, alpha-defensins and the cathelicidin LL-37/hCAP-18 originate from neutrophils. beta-Defensins and LL-...
متن کاملAntifungal peptides: novel therapeutic compounds against emerging pathogens.
The need for safe and effective antifungal agents increases in parallel with the expanding number of immunocompromised patients at risk for invasive fungal infections. The emergence of fungal pathogens resistant to current therapies further compounds the dearth of antifungal agents. Currently available antifungal compounds act on targets also found in mammalian cells (34), which may result in t...
متن کاملFunctions of Cationic Host Defense Peptides in Immunity
Cationic host defense peptides are a widely distributed family of immunomodulatory molecules with antimicrobial properties. The biological functions of these peptides include the ability to influence innate and adaptive immunity for efficient resolution of infections and simultaneous modulation of inflammatory responses. This unique dual bioactivity of controlling infections and inflammation ha...
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ژورنال
عنوان ژورنال: Pathogens and Global Health
سال: 2016
ISSN: 2047-7724,2047-7732
DOI: 10.1080/20477724.2016.1195036