Cathepsins in oral diseases

Cysteine Protease Cathepsins in Atherosclerotic Cardiovascular Diseases

Atherosclerotic cardiovascular disease (ASCVD) is an inflammatory disease characterized by extensive arterial wall matrix protein degradation. Cysteine protease cathepsins play a pivotal role in extracellular matrix (ECM) remodeling and have been implicated in the development and progression of atherosclerosis-based cardiovascular diseases. An imbalance in expression between cathepsins (such as...

Oral diseases

Neuronal and microglial cathepsins in aging and age-related diseases.

It has been long believed that cathepsins compensate for each other because of their overlapping substrate specificities. However, there is increasing evidence that disturbance of the normal balance of their enzymatic activities is the first insult in brain aging and age-related diseases. The imbalance of cathepsins may further cause age-related neuropathological changes such as accumulation of...

Islamic fasting and oral health and diseases

Fasting is a religious obligation, which can be challenging for individuals with oral conditions due to its stringent code of conduct. Moreover, food abstinence during fasting can restrict oral feeding even further in patients whose nutrition has been already compromised. Previous research has mainly concentrated on oral hygiene and gum health, disregarding orodental conditions and diseases. Th...

Cathepsins in digestive cancers

Cathepsins are lysosomal peptidases belonging to the papain family, and based on their catalytic sites, these enzymes can be divided into serine, cysteine and aspartic proteases. The studies conducted to date have identified, 15 types of cathepsins that are widely distributed in intracellular and extracellular spaces. These proteases participate in various pathological activities, including the...