منابع مشابه
Cathepsin E (EC 3.4.23.34)--a review.
Cathepsin E belongs to the third class of enzymes - hydrolases, a subclass of peptide bond hydrolases and a sub-subclass of endopeptidases with aspartic catalytic sites. Cathepsin E is an endopeptidase with substrate specificity similar to that of cathepsin D. In a human organism, cathepsin E occurs in: erythrocytes, thymus, dendritic cells, epithelial M cells, microglia cells, Langerhans cells...
متن کاملEC NEUROLOGY Mini Review Apolipoprotein E in Alzheimer’s Disease
The pathophysiology of Alzheimer’s disease (AD) is related with the ongoing deterioration of brain lipid homeostasis, in which the cholesterol transporter apolipoprotein E (APOE) plays a key role. Plasma protein APOE might be additionally associated with AD due to its capability to bind the amyloid protein. There are three principal isoforms: APOE2, APOE3 and APOE4, encoded by three different a...
متن کاملCathepsin S. The cysteine proteinase from bovine lymphoid tissue is distinct from cathepsin L (EC 3.4.22.15).
Cathepsin S was purified from bovine spleen by acid autolysis, (NH4)2SO4 fractionation and chromatography on CM-Sephadex C-50, CM-cellulose and activated-thiol-Sepharose. Cathepsin L was isolated from lysosomal fractions of rat liver, rat kidney and bovine liver. Generally, cathepsin L was bound tightly to CM-Sephadex C-50. Preparations of cathepsin L from rat liver, rat kidney and bovine liver...
متن کاملThe role of cathepsin E in terminal differentiation of keratinocytes.
Cathepsin E (CatE) is predominantly expressed in the rapidly regenerating gastric mucosal cells and epidermal keratinocytes, in addition to the immune system cells. However, the role of CatE in these cells remains unclear. Here we report a crucial role of CatE in keratinocyte terminal differentiation. CatE deficiency in mice induces abnormal keratinocyte differentiation in the epidermis and hai...
متن کاملCorrection: Cathepsin E Deficiency Impairs Autophagic Proteolysis in Macrophages
Citation: The PLOS ONE Staff (2014) Correction: Cathepsin E Deficiency Impairs Autophagic Proteolysis in Macrophages. PLoS ONE 9(5): e99278. doi:10.1371/ journal.pone.0099278 Published May 27, 2014 Copyright: 2014 The PLOS ONE Staff. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduct...
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ژورنال
عنوان ژورنال: Folia Histochemica et Cytobiologica
سال: 2012
ISSN: 1897-5631,0239-8508
DOI: 10.5603/fhc.2011.0078