Cathepsin D Associates with Lysosomal Membranous Protein.
نویسندگان
چکیده
منابع مشابه
Proteolytic Characterization and Lysosomal Localization of Echinoderm Cathepsin D
Cathepsin D is an important lysosomal aspartic protease and is transported to the lysosomes in both mannose 6-phosphate dependent and independent manner. The present study reports lysosomal transport and proteolytic characterization of cathepsin D purified from gonads of starfish Asterias Rubens. Activity of the purified enzyme was confirmed by a zymogram assay on hemoglobin. Characterization o...
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Cathepsin D-deficient (CD-/-) mice have been shown to manifest seizures and become blind near the terminal stage [approximately postnatal day (P) 26]. We therefore examined the morphological, immunocytochemical, and biochemical features of CNS tissues of these mice. By electron microscopy, autophagosome/autolysosome-like bodies containing part of the cytoplasm, granular osmiophilic deposits, an...
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 1995
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.18.1340