Catalytic Asymmetric Friedel-Crafts Reaction
نویسندگان
چکیده
منابع مشابه
Catalytic asymmetric tandem Friedel–Crafts alkylation/Michael addition reaction for the synthesis of highly functionalized chromans
The enantioselective tandem Friedel-Crafts alkylation/Michael addition reaction of indoles with nitroolefin enoates catalyzed by a diphenylamine-linked bis(oxazoline)-Zn(OTf)2 complex was investigated. This tandem reaction afforded functionalized chiral chromans in good yields with moderate to high stereoselectivities (up to 95:5 dr, up to 99% ee).
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The tandem Friedel-Crafts conjugate addition/asymmetric protonation reaction between 2-substituted indoles and methyl 2-acetamidoacrylate is reported. The reaction is catalyzed by (R)-3,3'-dibromo-BINOL in the presence of stoichiometric SnCl(4), and is the first example of a tandem conjugate addition/asymmetric protonation reaction using a BINOL·SnCl(4) complex as the catalyst. A range of indol...
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The indole skeleton is the most universal heterocycle structure in nature and is well established as a privileged scaffold; it is commonly encountered in many biologically active natural products and pharmaceutical compounds. Owing to the great structural diversity of biologically active indoles, indole units are of great importance in medicinal chemistry and are widely used in the pharmaceutic...
متن کاملDeciphering DNA-based asymmetric catalysis through intramolecular Friedel-Crafts alkylations.
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ژورنال
عنوان ژورنال: Journal of Synthetic Organic Chemistry, Japan
سال: 2008
ISSN: 0037-9980,1883-6526
DOI: 10.5059/yukigoseikyokaishi.66.249