Catalytic addition of CH bonds to multiple bonds

Multiple metal-carbon bonds for catalytic metathesis reactions (Nobel Lecture).

7 Activation of H – AHn and CH 3 – AHn bonds

We have studied the palladium oxidative insertion reactions into a series of model bonds across the second period, that is, the H–AHn and CH3–AHn bonds, where AHn = CH3, NH2, OH, and F. We investigate what effect this series of increasingly polar bonds has on their intrinsic barriers upon activation by palladium. Our activation strain analyses show nicely how the observed trends are strongly in...

6 Analysis of H – AHn and CH 3 – AHn bonds

Along the series of H–AHn bonds, with AHn = CH3, NH2, OH, and F, the bond dissociation energies show a steady increase as can be expected from the increasing difference in electronegativity along this series. However, in the same series for CH3– AHn the bond strength first decreases from CH3–CH3 to CH3–NH2 and only thereafter increases again along CH3–NH2, CH3–OH and CH3–F. To understand the or...

Aminoboration: Addition of B–N σ Bonds across C–C π Bonds

This communication demonstrates the first catalytic aminoboration of C-C π bonds by B-N σ bonds and its application to the synthesis of 3-borylated indoles. The regiochemistry and broad functional group compatibility of this addition reaction enable substitution patterns that are incompatible with major competing technologies. This aminoboration reaction effects the formation of C-B and C-N bon...

CH...O hydrogen bonds at protein-protein interfaces.

For the first time, a statistical potential has been developed to quantitatively describe the CH.O hydrogen bonding interaction at the protein-protein interface. The calculated energies of the CH.O pair interaction show a favorable valley at approximately 3.3 A, exhibiting a feature typical of an H-bond and similar to the ab initio quantum calculation result (Scheiner, S., Kar, T., and Gu, Y. (...