Caspofungin
نویسندگان
چکیده
منابع مشابه
Innovative Therapy with Caspofungin.
A 68 year old gentleman suffered subarachnoid and intra-ventricular hemorrhage due to a basilar artery aneurysm, which was clipped. He needed multiple changes of external ventricular drain and Ommaya reservoir due to blocks. This led to nosocomial Candida albicans meningitis which was worsening despite 10 days of treatment with L AmB and 5FC to which the organism was susceptible. The susceptibi...
متن کاملStimulation of Eryptosis by Caspofungin.
BACKGROUND/AIMS The echinocandin antifungal agent caspofungin has been shown to trigger apoptosis of fungal cells. Beyond that, caspofungin is toxic for host mitochondria. Even though lacking mitochondria, erythrocytes may enter apoptosis-like suicidal erythrocyte death or eryptosis, characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine translocation to the erythr...
متن کاملCaspofungin disk diffusion breakpoints and quality control.
Interpretive disk diffusion breakpoints for caspofungin are proposed by evaluating 762 isolates of Candida spp., representing 10 different species obtained as part of the caspofungin clinical trials. Standardized broth microdilution reference tests were compared to the zone diameters observed with 5-microg caspofungin disks produced by two different disk manufacturers. Disk diffusion breakpoint...
متن کاملCandida glabrata endophthalmitis treated successfully with caspofungin.
A 39-year-old man with Candida glabrata endophthalmitis was successfully treated with a 28-day course of intravenous caspofungin. Presence of underlying renal insufficiency and infection with a drug-resistant strain precluded use of amphotericin B or fluconazole. Intravitreal administration of antifungals and vitrectomy were not required. The role of caspofungin in Candida endophthalmitis is di...
متن کاملEmergence of Candida tropicalis resistant to caspofungin.
Sir, Candida species is the fourth leading cause of nosocomial bloodstream infection in the USA. The incidence and mortality of invasive candidiasis (IC) remain high despite new antifungal agents. Although Candida albicans remains the most common isolated species causing IC, the incidence of IC caused by non-albicans species is increasing. Caspofungin, an echinocandin, is approved for treatment...
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ژورنال
عنوان ژورنال: Clinical Infectious Diseases
سال: 2003
ISSN: 1537-6591,1058-4838
DOI: 10.1086/375080