منابع مشابه
Caspases play in traffic
The unfolding of apoptosis involves the orchestrated proteolysis of hundreds of proteins, and to achieve efficacy the cell has evolved a three-step activation cascade. First, initiator caspases (caspases 8, 9, 10) are activated either by external death ligands triggering the formation of the death-inducing signaling complex (DISC; caspases 8 and 10) or by the release of cytochrome c from mitoch...
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U ncontrolled lymphoproliferation is a characteristic feature of lymphomas and leukemias. Nonmalignant lym-phoproliferative diseases are also observed in humans as well as in lpr (lymphoproliferation) and gld (generalized lymphad-enopathy) mice. The discoveries that spontaneous mutations of Fas (APO-1/CD95) or its ligand (FasL) were associated with the lpr and gld phenotypes led to a satisfying...
متن کاملDeath without caspases, caspases without death.
Apoptosis is a conserved cell-death process displaying characteristic morphological and molecular changes including activation of caspase proteases. Recent work challenges the accepted roles of these proteases. New investigations in mice and the nematode Caenorhabditis elegans suggest that there could be caspase-independent pathways leading to cell death. In addition, another type of cell death...
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In AD, a significant synaptic loss ranging from 20% to 50% is reported. Biochemistry, elec‐ tron microscopy and immunocytochemistry have shown a decrease in synaptic density, presynaptic terminals, synaptic vesicle and synaptic protein markers in AD brains com‐ pared with the normal aged controls (Terry et al., 1991; Geula, 1998; Larson et al., 1999; Yao et al., 1999; Ashe, 2000; Baloyannis et ...
متن کاملCoSign: A Fictitious Play Algorithm for Coordinated Traffic Signal Control
The problem of finding efficient coordinated signal timing plans for a large number of traffic signals is a challenging problem because of the exponential growth in the number of joint timing plans that need to be explored as the network size grows. In this paper, we employ the game-theoretic paradigm of fictitious play to iteratively converge to a locally optimal coordinated signal timing plan...
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ژورنال
عنوان ژورنال: Cell Death & Disease
سال: 2017
ISSN: 2041-4889
DOI: 10.1038/cddis.2017.55