منابع مشابه
Death without caspases, caspases without death.
Apoptosis is a conserved cell-death process displaying characteristic morphological and molecular changes including activation of caspase proteases. Recent work challenges the accepted roles of these proteases. New investigations in mice and the nematode Caenorhabditis elegans suggest that there could be caspase-independent pathways leading to cell death. In addition, another type of cell death...
متن کاملRoles of Caspases in Necrotic Cell Death
Caspases were originally identified as important mediators of inflammatory response and apoptosis. Recent discoveries, however, have unveiled their roles in mediating and suppressing two regulated forms of necrotic cell death, termed pyroptosis and necroptosis, respectively. These recent advances have significantly expanded our understanding of the roles of caspases in regulating development, a...
متن کاملCell Death Inhibition Keeping Caspases in Check
Upon viral infection, cells commit suicide and die by Successful implosion of a building depends on the preapoptosis as an altruistic defense mechanism to benefit cise and timely detonation of explosives. If a cell underthe organism. Several viruses have built into their gegoing apoptosis is analogous to an imploding building, nome apoptosis-inhibiting arsenal, including proteins then the explo...
متن کاملCaspases: pharmacological manipulation of cell death.
Caspases, a family of cysteine proteases, play a central role in apoptosis. During the last decade, major progress has been made to further understand caspase structure and function, providing a unique basis for drug design. This Review gives an overview of caspases and their classification, structure, and substrate specificity. We also describe the current knowledge of how interference with ca...
متن کاملCell death independent of caspases: a review.
Patterns of cell death have been divided into apoptosis, which is actively executed by specific proteases, the caspases, and accidental necrosis. However, there is now accumulating evidence indicating that cell death can occur in a programmed fashion but in complete absence and independent of caspase activation. Alternative models of programmed cell death (PCD) have therefore been proposed, inc...
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ژورنال
عنوان ژورنال: IUBMB Life
سال: 1999
ISSN: 1521-6543
DOI: 10.1080/713803494