منابع مشابه
Wilderness Management Dilemmas: Fertile Ground for Wilderness Management Research
Increasingly, wilderness managers must choose between the objective of wildness (“untrammeled” wilderness) and the objectives of naturalness and solitude. This dilemma has surfaced with awareness of the pervasiveness of human influence in wilderness and that regulation is often the only way to maintain outstanding opportunities for solitude. Should we trammel wilderness to compensate for unnatu...
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Purinergic signaling is a primitive and highly conserved system between animals. Nucleotides (e.g. ATP, ADP) and nucleosides (e.g. adenosine) may act as cellular messengers when getting the extracellular space and binding purinoceptors. In the cardiovascular system, nucleotides may either lead to vasoconstriction when activating VSMC P2 receptors or vasorelaxation by the activation of endotheli...
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The core effectors of apoptosis encompass proteolytic enzymes of the caspase family, which reside as latent precursors in most nucleated metazoan cells. A majority of studies on apoptosis are based on the assumption that caspase precursors are activated by cleavage, a common mechanism for most protease zymogen activations. Although this appears to be true for the executioner caspases, recent re...
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Huntington's disease results from a mutation in the HD gene encoding for the protein huntingtin. The function of huntingtin, although beginning to be elucidated, remains largely unclear. To probe the prosurvival function of huntingtin, we modulate levels of wild-type huntingtin in a number of cellular and in vivo models. Huntingtin depletion resulted in caspase-3 activation, and overexpression ...
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ژورنال
عنوان ژورنال: Developmental Cell
سال: 2003
ISSN: 1534-5807
DOI: 10.1016/s1534-5807(03)00134-5