Caspase-7 Is Directly Activated by the ∼700-kDa Apoptosome Complex and Is Released as a Stable XIAP-Caspase-7 ∼200-kDa Complex
نویسندگان
چکیده
منابع مشابه
Structural Basis of Caspase-7 Inhibition by XIAP
The inhibitor of apoptosis (IAP) proteins suppress cell death by inhibiting the catalytic activity of caspases. Here we present the crystal structure of caspase-7 in complex with a potent inhibitory fragment from XIAP at 2.45 A resolution. An 18-residue XIAP peptide binds the catalytic groove of caspase-7, making extensive contacts to the residues that are essential for its catalytic activity. ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2006
ISSN: 0021-9258
DOI: 10.1074/jbc.m507393200