منابع مشابه
Local pruning of dendrites and spines by caspase-3-dependent and proteasome-limited mechanisms.
Synapse loss occurs normally during development and pathologically during neurodegenerative disease. Long-term depression, a proposed physiological correlate of synapse elimination, requires caspase-3 and the mitochondrial pathway of apoptosis. Here, we show that caspase-3 activity is essential--and can act locally within neurons--for regulation of spine density and dendrite morphology. By phot...
متن کاملSynapse efficiency diverges due to synaptic pruning following overgrowth.
In the development of the brain, it is known that synapses are pruned following overgrowth. This pruning following overgrowth seems to be a universal phenomenon that occurs in almost all areas-visual cortex, motor area, association area, and so on. It has been shown numerically that the synapse efficiency is increased by systematic deletion. We discuss the synapse efficiency to evaluate the eff...
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Aims. Accurate measurement of gravitational shear from images of distant galaxies is one of the most direct ways of studying the distribution of mass in the universe. We describe an implementation of a technique that is based on the shapelets formalism. Methods. The shapelets technique describes PSF and observed images in terms of Gauss-Hermite expansions (Gaussians times polynomials). It allow...
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Caspase-3, one of the dominant effectors caspases, is activated in almost every model of apoptosis with various signaling pathways. Hence, inhibition of caspase-3 has become an attractive target in the treatment of neurodegenerative diseases. Caspase-3 inhibitory activities of some 1,2-benzisothiazol-3-one derivatives were modeled by quantitative structure–activity relationship (QSAR) using ste...
متن کاملQSAR Analysis for Some 1, 2-Benzisothiazol-3-one Derivatives as Caspase-3 Inhibitors by Stepwise MLR Method
Caspase-3, one of the dominant effectors caspases, is activated in almost every model of apoptosis with various signaling pathways. Hence, inhibition of caspase-3 has become an attractive target in the treatment of neurodegenerative diseases. Caspase-3 inhibitory activities of some 1,2-benzisothiazol-3-one derivatives were modeled by quantitative structure–activity relationship (QSAR) using ste...
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ژورنال
عنوان ژورنال: Developmental Cell
سال: 2014
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2014.03.010