Caspase-1 Mediates Resistance in Murine Melioidosis

Caspase-1 mediates resistance in murine melioidosis.

The gram-negative rod Burkholderia pseudomallei is the causative agent of melioidosis, a potentially fatal disease which is endemic in tropical and subtropical areas. The bacterium multiplies intracellularly within the cytosol, induces the formation of actin tails, and can spread directly from cell to cell. Recently, it has been shown that B. pseudomallei can induce caspase-1-dependent cell dea...

Enzymatically inactive caspase-1 mediates a proinflammatory phenotype in mice

Introduction The proinflammatory enzyme caspase-1 belongs to the family of cystein proteases and plays a pivotal role in innate immunity. Classically, caspase-1 mediated proinflammatory signaling is thought to be dependent on its enzymatic activity. Interestingly, a number of patients carrying variants of the CASP1 gene show proinflammatory symptoms like febrile episodes despite of reduced enzy...

Microvesicular Caspase-1 Mediates Lymphocyte Apoptosis in Sepsis

OBJECTIVE Immune dysregulation during sepsis is poorly understood, however, lymphocyte apoptosis has been shown to correlate with poor outcomes in septic patients. The inflammasome, a molecular complex which includes caspase-1, is essential to the innate immune response to infection and also important in sepsis induced apoptosis. Our group has recently demonstrated that endotoxin-stimulated mon...

Caspase-1 mediates hyperlipidemia-weakened progenitor cell vessel repair.

Caspase-1 activation senses metabolic danger-associated molecular patterns (DAMPs) and mediates the initiation of inflammation in endothelial cells. Here, we examined whether the caspase-1 pathway is responsible for sensing hyperlipidemia as a DAMP in bone marrow (BM)-derived Stem cell antigen-1 positive (Sca-(1+)) stem/progenitor cells and weakening their angiogenic ability. Using biochemical ...

Equine Melioidosis in Iran