Case Report: A 65-year-old man with paraganglioma accompanied by elevated interleukin-6 levels and KIF1B single gene mutation

Paraganglioma is a less prevalent disease, and paraganglioma with only secreting interleukin-6 (IL-6) has not been previously reported. A 64-year-old male patient came to the hospital chief complaints of fever palpitations. The peak body temperature was 38.7°C (101.66°F). Heart rate 110 bpm, while blood pressure in normal range. Antibiotics antiviral therapies were ineffective. levels IL-6, C-reactive protein (CRP), alkaline phosphatase (ALP), platelets (PLT), glutamyltransferase (GGT), fibrinogen, D-dimer all elevated. Infectious diseases, auto-immune hematological malignancy excluded. Nearly 10 years ago, large retroperitoneal mass detected by accident. Fortunately, there have no special symptoms for past after regular follow-up. After admission this time, PET-CT performed. confounding density at upper part abdominal area seen, possibility considered. However, biochemical assays urine catecholamine their metabolites including adrenaline, norepinephrine, 3-methoxytyramine, methoxyepinephrine, methoxynorepinephrine, vanillylmandelic acid range spite mild elevated dopamine significance. whole-exome capture sequencing genomic DNA showed heterozygous mutation coding site KIF1B gene (Coding: NM_015047.3:c.4660G>C, Mutation: p.Val1554Leu; chromosomal location chr1: 10428570). locus reported previously. refused surgical treatment. Because burdens several important organs pancreas, risk surgery high. Doxazosin then administered patient. taking doxazosin, disappeared rapidly. Body returned 3 days. decreased approximately 90 bpm. In following days, CPR, ALP, platelets, GGT continued decrease. 63 days IL-6 level completely normal. 190 medication, hemoglobin (Hb) also 1 year onset, again underwent test. Almost indexes IL-6.