Case of juvenile dermatomyositis (JDM), thrombotic thrombocytopenic purpura (TTP), and Purtscher retinopathy
نویسندگان
چکیده
منابع مشابه
Case of juvenile dermatomyositis (JDM), thrombotic thrombocytopenic purpura (TTP), and Purtscher retinopathy
Methods Here we describe a previously healthy and athletic 12 year old female who was diagnosed with JDM following a period of two weeks of pruritic rash, fever, headaches, muscle pain and weakness. Her work-up was significant for elevated muscle enzymes and an abnormal MRI of bilateral quadriceps that demonstrated increased signal intensity. The patient was hospitalized for intravenous pulse m...
متن کاملA difficult case of juvenile dermatomyositis complicated by thrombotic microangiopathy and purtscher-like retinopathy
Results A 16 year old girl was admitted for fever, diffuse pain, asthenia, sore throat and generalised papular rash. Initial work-up showed leukopenia, elevation in creatine phosphokinase (CK) (650 U/l) and transaminase. Epstein-Barr Virus (EBV) serology was compatible with acute infection and the initial treatment was symptomatic. Subsequent deterioration of general conditions, progressive pol...
متن کاملPlasmapheresis in thrombotic thrombocytopenic purpura (TTP)
A 70-year-old woman with thrombotic thrombocytopenic purpura (TTP) was treated with plasmapheresis using fresh frozen plasma as a fluid replacement. Complete recovery and lasting remission were observed. It appears that plasmapheresis combined with massive fresh frozen plasma can be an effective mode of treatment for patients who were, otherwise, refractory to conventional therapy.
متن کاملIpilimumab-induced thrombotic thrombocytopenic purpura (TTP)
BACKGROUND CTLA-4 (Cytotoxic T-lymphocyte-associated protein 4) was the first immune checkpoint receptor clinically targeted for use in cancer treatment. It is expressed exclusively on T-cells where its primary role is to regulate the amplitude of the early stages of T-cell activation.1 Ipilimumab, a CTLA-4 blocking antibody, has been widely used for the treatment of patients with high risk and...
متن کاملHereditary thrombotic thrombocytopenic purpura and the hereditary TTP registry.
Hereditary thrombotic thrombocytopenic purpura, Upshaw-Schulman syndrome, ADAMTS13 Hereditary thrombotic thrombocytopenic purpura (TTP), also known as Upshaw-Schulman syndrome, is a rare recessively inherited disease. Underlying is a severe constitutional deficiency of the von Willebrand factor-cleaving protease, ADAMTS13, due to compound heterozygous or homozygous mutations in the ADAMTS13 gen...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Pediatric Rheumatology
سال: 2012
ISSN: 1546-0096
DOI: 10.1186/1546-0096-10-s1-a66