Case 193: Neuroferritinopathy—A Brain Iron Accumulation and Neurodegenerative Disorder
نویسندگان
چکیده
منابع مشابه
Brain blood barrier defects and ferric-iron brain accumulation as cause of gradually neurodegenerative brain disease
As a main aim we want to focus on the sources of oxidants as key factors in understanding the role oxidants play in the pathogenesis of brain vascular endothelial dysfunction. The question remains whether iron inversion and subsequent radical formation is a primary or secondary event in neurodegenerative disease. Recent research suggests that iron inversion is an initial cause of neuronal cell ...
متن کاملPsychotic Disorder in Neurodegeneration with Brain Iron Accumulation.
Introduction Neurodegeneration with brain iron accumulation (NBIA) refers to a group of disorders that are characterized by iron accumulation, particularly in the basal ganglia (1). This process results in progressive dystonia, spasticity, Parkinsonism, neuropsychiatric abnormalities, optic atrophy or retinal degeneration. The worldwide prevalence of NBIA has been estimated at 1:1,000,000. The ...
متن کاملNeurodegeneration with brain iron accumulation: A case report
Pantothenate kinase-associated neurodegeneration (PKAN) is an autosomal recessive disorder caused by mutation in the PANK2 gene. It is characterized by abnormal brain iron accumulation, mainly in the globus pallidus. PKAN is included in a group of disorders known as neurodegeneration with brain iron accumulation (NBIA). We report a case of atypical PKAN with its most characteristic presentation...
متن کاملNeurodegeneration with brain iron accumulation.
Neurodegeneration with brain iron accumulation (NBIA) describes a group of progressive extrapyramidal disorders with radiographic evidence of focal iron accumulation in the brain, usually in the basal ganglia. Patients previously diagnosed with Hallervorden-Spatz syndrome fall into this category. Mutations in the PANK2 gene account for the majority of NBIA cases and cause an autosomal recessive...
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The acute stage of moderate-severe traumatic brain injury (TBI) entails the rapid unfolding of pathophysiological processes secondary to biomechanical damage that eventually stabilize, typically leaving a combination of focal damage (visible as encephalomalacia) and more widespread lesions, both to the white matter (known as traumatic axonal injury) and to the microvasculature of the brain (Pov...
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ژورنال
عنوان ژورنال: Radiology
سال: 2013
ISSN: 0033-8419,1527-1315
DOI: 10.1148/radiol.13111136