CARPs enhance p53 turnover by degrading 14-3-3σ and stabilizing MDM2
نویسندگان
چکیده
منابع مشابه
14-3-3sigma, a p53 regulator, suppresses tumor growth of nasopharyngeal carcinoma.
The 14-3-3sigma gene product, up-regulated by p53 in response to DNA damage, is involved in cell-cycle checkpoint control and is a human cancer epithelial marker down-regulated in various tumors. However, its role and function have not been established in nasopharyngeal carcinoma (NPC), a tumor of epithelial origin. Recently, we found that 14-3-3sigma interacts with p53 in response to DNA damag...
متن کاملEpigenetic silencing of 14-3-3sigma in cancer.
The 14-3-3sigma gene is a direct target of the p53 tumor suppressor and its product inhibits cell cycle progression. Recently, a proteomic analysis revealed that 14-3-3sigma regulates additional cellular processes relevant to carcinogenesis, as migration and MAP-kinase signalling. The expression of 14-3-3sigma is down-regulated by CpG methylation in several types of human cancer, among them pro...
متن کامل14-3-3 Regulates Actin Dynamics by Stabilizing Phosphorylated Cofilin
The functionality of the actin cytoskeleton depends on a dynamic equilibrium between filamentous and monomeric actin. Proteins of the ADF/cofilin family are essential for the high rates of actin filament turnover observed in motile cells through regulation of actin polymerization/depolymerization cycles. Rho GTPases act through p21-activated kinase-1 (Pak-1) and Rho kinase to inhibit cofilin ac...
متن کاملCARPs are ubiquitin ligases that promote MDM2-independent p53 and phospho-p53ser20 degradation.
Caspase 8/10-associated RING proteins (CARPs) are a recently described family of protein ubiquitin ligases that interact with and negatively regulate death receptor-mediated apoptosis. Because CARPs are overexpressed in cancer and their silencing reduces cell viability and sensitizes tumor cells to chemotherapeutic agents, we investigated their relationship to p53 tumor suppressor signaling. p5...
متن کاملNon-Starch Polysaccharide Degrading Gut Bacteria in Indian Major Carps and Exotic Carps
Cellulose and xylan are the most common Non-Starch Polysaccharides (NSPs); they are available in plants and they exhibit anti-nutritional effects. The present study is intended to detect cellulose and xylan degrading autochthonous gut bacteria in Indian major carps (Labeo rohita, Catla catla, and Cirrhinus mrigala) and exotic carps (Hypophthalmichthys molitrix, Ctenopharyngodon idella, and Cypr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Cycle
سال: 2008
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.7.5.5701