Cardiovascular genomics
نویسندگان
چکیده
منابع مشابه
Cardiovascular genomics.
PURPOSE This article provides an update on cardiovascular genomics using three clinically relevant exemplars, including myocardial infarction (MI) and coronary artery disease (CAD), stroke, and sudden cardiac death (SCD). ORGANIZATIONAL CONSTRUCT: Recent advances in cardiovascular genomic research, testing, and clinical implications are presented. METHODS Genomic nurse experts reviewed and su...
متن کاملGenomics of cardiovascular disease.
From the National Heart, Lung, and Blood Institute and the Framingham Heart Study, National Institutes of Health, Bethesda, MD (C.J.O.); and Massachusetts General Hospital (C.J.O.), Brigham and Women’s Hospital (E.G.N.), and Harvard Medical School (C.J.O., E.G.N.) — all in Boston. Address reprint requests to Dr. Nabel at Brigham and Women’s Hospital, 75 Francis St., Boston, MA 02115, or at enab...
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Integrative genomics studies have greatly advanced our understanding of cardiovascular pathophysiology over the last decade. Here, we highlight the strengths and challenges of this cutting-edge approach and provide examples where novel insights have arisen through the integration of multi-level genomic information and cardiac physiology. Going forward, the integration of comprehensive next-gene...
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Cardiovascular disease (CVD) is a heterogeneous, complex trait that has a major impact on human morbidity and mortality. Common genetic variation may predispose to common forms of CVD in the community, and rare genetic conditions provide unique pathogenetic insights into these diseases. With the advent of the Human Genome Project and the genomic era, new tools and methodologies have revolutioni...
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The majority of modifiable cardiovascular risk factors are complex, polygenic, or at least oligogenic traits, with genetic and environmental determinants playing important roles in disease risk and its phenotypic expression. The Human Genome Project and subsequent mouse and rat genome data have provided powerful tools to commence the dissection of genetic determinants of hypertension and other ...
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ژورنال
عنوان ژورنال: Cardiovascular Pathology
سال: 2003
ISSN: 1054-8807
DOI: 10.1016/s1054-8807(03)00074-7