Cardiovascular autonomic nervous function in 7–12 years old children conceived naturally or by ART with frozen and fresh embryo transfer

Abstract Background Cardiovascular autonomic nervous functions (CANF) exert important homeostatic mechanisms to prevent major arterial blood pressure fluctuations by adjusting heart rate (HR), cardiac contractility, and peripheral vascular tone. Children conceived assisted reproductive technologies (ART) are at risk of increased carotid intima-media thickness, insulin resistance, stiffness, hypertension. CANF is impaired in children with obesity diabetes mellitus, conductance artery stiffness documented influence CANF. may therefore be hypothetized ART. Purpose This the first study investigate whether ART have as compared naturally children. Method was studied 105 singletons aged 7–12 years (NC, N=33) or (frozen embryo transfer (FET, N=34) fresh (Fresh ET, N=38)). evaluated continuous non-invasive hemodynamic measurements (Finapres®) HR changes seen relative rest during active standing, deep breathing Valsalva, respectively. Results The descriptive data showed no difference between our groups (Table 1). In multivariate analysis, only Valsalva HR-ratio significantly higher FET NC after adjustments for age, sex, BMI maternal age delivery (Figure For all meaures, effect size (Hedges d) ranged from 0.02 0.48. Conclusion this HR-response were statistically significant adjustment confounders, general sizes small. Our suggests that do not a cardiovascular function Funding Acknowledgement Type funding sources: Foundation. Main source(s): Novo Nordisk Foundation