منابع مشابه
Cardiotoxicity of Anticancer Therapeutics
As cancer therapeutics continues to improve and progress, the adverse side effects associated with anticancer treatments have also attracted more attention and have become extensively explored. Consequently, the importance of posttreatment follow-ups is becoming increasingly relevant to the discussion. Contemporary treatment methods, such as tyrosine kinase inhibitors, anthracycline chemotherap...
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Trastuzumab, a monoclonal antibody against the HER2 receptor, was recently approved for the treatment of metastatic breast cancer. However, 28% of patients receiving both an anthracycline and trastuzumab developed heart failure. Although HER2 overexpression has been associated with the development of cancer, HER2 receptors seem to be cardioprotective because they mediate the activation of impor...
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In the last two decades, significant advances in cancer therapy development have lead to more effective chemotherapeutic and novel targeted therapies for cancer patients. Although this has resulted in a remarkable improvement in cure rates and cancer-related survival, it has also resulted in unwanted long term side effects in a growing population of survivors. In recent years, cardiac toxicity ...
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Despite their recognized cardiotoxic effects, anthracyclines remain an essential component in many anticancer regimens due to their superior antitumor efficacy. Epidemiologic data revealed that about one-third of cancer patients have hypertension, which is the most common comorbidity in cancer registries. The purpose of this review is to assess whether anthracycline chemotherapy exacerbates car...
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Adriamycin, a widely used anthracycline antibiotic in multiple chemotherapy regimens, has been challenged by the cardiotoxicity leading to fatal congestive heart failure in the worst condition. The present study demonstrated that Dihydromyricetin, a natural product extracted from ampelopsis grossedentat, exerted cardioprotective effect against the injury in Adriamycin-administrated ICR mice. Di...
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ژورنال
عنوان ژورنال: Nature Reviews Cardiology
سال: 2016
ISSN: 1759-5002,1759-5010
DOI: 10.1038/nrcardio.2016.39